Supplementary Materials for:
TRPS1 Targeting by miR-221/222 Promotes the Epithelial-to-Mesenchymal Transition in Breast Cancer
Susanna Stinson, Mark R. Lackner, Alex T. Adai, Nancy Yu, Hyo-Jin Kim, Carol
O'Brien, Jill Spoerke, Suchit Jhunjhunwala, Zachary Boyd, Thomas Januario, Robert J.
Newman, Peng Yue, Richard Bourgon, Zora Modrusan, Howard M. Stern, Søren
Warming, Frederic J. de Sauvage, Lukas Amler, Ru-Fang Yeh, David Dornan*
*To whom correspondence should be addressed. E-mail: dornan.david{at}gene.com
This PDF file includes:
- Materials and Methods
- References
- Fig. S1. Plot of miR-221, miR-222, and miR-200c expression across luminal and
basal-like cell lines.
- Fig. S2. Triple-negative breast cancers have more abundant miR-221/222 than
ER/PR breast cancers.
- Fig. S3. Phase contrast and immunofluorescence images of MCF10A cells
transfected with miR-221/222.
- Fig. S4. miR-221/222 abundance correlates with that of the mRNA encoding
vimentin.
- Fig. S5. miR-221/222 abundance inversely correlates with that of the mRNA
encoding E-cadherin.
- Fig. S6. miR-221/222 abundance inversely correlates with that of the mRNA
encoding TRPS1.
- Table S1. Luminal-basal specific differential gene expression.
- Table S2. miR-221/222 gene targets down-regulated in basal-like subtype and in
MCF10A cells overexpressing miR-221/222.
- Table S3. Filtered candidate target genes for miR-221/222 based on CRS.
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Citation: S. Stinson, M. R. Lackner, A. T. Adai, N. Yu, H.-J. Kim, C. O'Brien, J. Spoerke,
S. Jhunjhunwala, Z. Boyd, T. Januario, R. J. Newman, P. Yue, R. Bourgon, Z. Modrusan,
H. M. Stern, S. Warming, F. J. de Sauvage, L. Amler, R.-F. Yeh, D. Dornan, TRPS1 Targeting by miR-221/222 Promotes
the Epithelial-to-Mesenchymal Transition
in Breast Cancer.
Sci. Signal. 4, ra41 (2011).
© 2011 American Association for the Advancement of Science
