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Sci. Signal., 9 August 2011
[DOI: 10.1126/scisignal.2001748]

Supplementary Materials for:

Quantitative Encoding of the Effect of a Partial Agonist on Individual Opioid Receptors by Multisite Phosphorylation and Threshold Detection

Elaine K. Lau, Michelle Trester-Zedlitz, Jonathan C. Trinidad, Sarah J. Kotowski, Andrew N. Krutchinsky, Alma L. Burlingame, Mark von Zastrow*

*To whom correspondence should be addressed. E-mail: mark.vonzastrow{at}ucsf.edu

This PDF file includes:

  • Fig. S1. LC-ESI MS/MS analysis of peptide 1.
  • Fig. S2. LC-ESI QTRAP analysis of peptides 1 and 2.
  • Fig. S3. LC-ESI MS/MS analysis of peptide 4.
  • Fig. S4. LC-ESI MS/MS analysis of peptide 5.
  • Table S1. Table of observed and calculated mass-to-charge values of phosphorylated tryptic digest products of MOR.
  • Table S2. Reference table of raw and adjusted signals.

[Download PDF]

Technical Details

Format: Adobe Acrobat PDF

Size: 282 KB


Citation: E. K. Lau, M. Trester-Zedlitz, J. C. Trinidad, S. J. Kotowski, A. N. Krutchinsky, A. L. Burlingame, M. von Zastrow, Quantitative Encoding of the Effect of a Partial Agonist on Individual Opioid Receptors by Multisite Phosphorylation and Threshold Detection. Sci. Signal. 4, ra52 (2011).

© 2011 American Association for the Advancement of Science


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