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Sci. Signal., 20 September 2011
[DOI: 10.1126/scisignal.2002221]

Supplementary Materials for:

A Synthetic Biology Approach Reveals a CXCR4-G13-Rho Signaling Axis Driving Transendothelial Migration of Metastatic Breast Cancer Cells

Hiroshi Yagi, Wenfu Tan, Patricia Dillenburg-Pilla, Sylvain Armando, Panomwat Amornphimoltham, May Simaan, Roberto Weigert, Alfredo A. Molinolo, Michel Bouvier, J. Silvio Gutkind*

*To whom correspondence should be addressed. E-mail: sg39v{at}nih.gov

This PDF file includes:

  • Fig. S1. CXCR4 mediates spontaneous metastatic spread of breast cancer cells.
  • Fig. S2. Gα12/13 abundance correlates with prognosis of breast cancer patients and the metastatic properties of breast cancer cell lines.
  • Fig. S3. The migration of metastatic breast cancer cells requires the activation of Gα13-Rho signaling axis.
  • Fig. S4. ROCK inhibitors may provide an approach to preventing breast cancer metastasis.
  • References

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Technical Details

Format: Adobe Acrobat PDF

Size: 2.4 MB


Citation: H. Yagi, W. Tan, P. Dillenburg-Pilla, S. Armando, P. Amornphimoltham, M. Simaan, R. Weigert, A. A. Molinolo, M. Bouvier, J. S. Gutkind, A Synthetic Biology Approach Reveals a CXCR4-G13-Rho Signaling Axis Driving Transendothelial Migration of Metastatic Breast Cancer Cells. Sci. Signal. 4, ra60 (2011).

© 2011 American Association for the Advancement of Science


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