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Sci. Signal., 11 October 2011
[DOI: 10.1126/scisignal.2002152]

Supplementary Materials for:

Load-Induced Modulation of Signal Transduction Networks

Peng Jiang, Alejandra C. Ventura, Eduardo D. Sontag, Sofia D. Merajver, Alexander J. Ninfa,* Domitilla Del Vecchio*

*To whom correspondence should be addressed. E-mail: aninfa{at}umich.edu (A.J.N.); ddv{at}mit.edu (D.D.V.)

This PDF file includes:

  • Text
  • Fig. S1. Steady-state effects of loading.
  • Fig. S2. Effect of loading on the frequency response.
  • Fig. S3. Effects of enzyme amounts.
  • Fig. S4. Effect of the load on the amplitude of response to a train of pulses.
  • Fig. S5. Response of the UTase/UR–PII cycle to stimulation with nonsaturating concentrations of glutamine.
  • Fig. S6. Using glutaminase and injections of glutamine to impose time-varying input stimulation.
  • Fig. S7. Amplitude of the initial response to glutamine addition depends on whether or not the system has achieved a steady state before glutamine addition.
  • References

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Technical Details

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Other Supplementary Material for this manuscript includes the following:

  • SimulinkModel (.mdl file)

[Download SimulinkModel (Compressed)]

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Citation: P. Jiang, A. C. Ventura, E. D. Sontag, S. D. Merajver, A. J. Ninfa, D. Del Vecchio, Load-Induced Modulation of Signal Transduction Networks. Sci. Signal. 4, ra67 (2011).

© 2011 American Association for the Advancement of Science


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