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Sci. Signal., 18 October 2011
[DOI: 10.1126/scisignal.2002165]

Interactive Figures for:

Structural Basis for Activation and Inhibition of Class I Phosphoinositide 3-Kinases (Interactive Figures 3A and 3B)

Oscar Vadas*, John E. Burke, Xuxiao Zhang, Alex Berndt, and Roger L. Williams*

*To whom correspondence should be addressed.  E-mail: ovadas{at}mrc-lmb.cam.ac.uk (O.V.); rlw{at}mrc-lmb.cam.ac.uk (R.L.W.)

Interactive image 1. The regulatory arch. This illustration is based on PDB entries 2Y3A (p110β and p85β) and 3HHM (p110α and p85α) and is visualized with JMOL (1). This is an interactive version of the molecular structure shown in Figure 3A. The static image to the right is the same one that appears in the full text.

CREDIT: R. L. WILLIAMS/MEDICAL RESEARCH COUNCIL, LABORATORY OF MOLECULAR BIOLOGY, UK

[View interactive image 1]

Interactive image 2. The regulatory arch for class I and III enzymes, colored by isotype. This illustration is based on PDB entries 2RD0 (wild-type p110α), 3HHM (p110α H1047R), 2Y3A (p110β), 2WXG (p110δ), 1E8X (p110γ), and 2X6H (Vps34) and is visualized with JMOL (1).  This is an interactive version of the molecular structure shown in Figure 3B. The static image to the right is the same one that appears in the full text.

CREDIT: R. L. WILLIAMS/MEDICAL RESEARCH COUNCIL, LABORATORY OF MOLECULAR BIOLOGY, UK

[View interactive image 2]

Tips for using the JMOL applet (1). To move the image, click in the image and hold the mouse button down and move the mouse. To zoom in or out, click in the image and hold down the mouse button with the "Shift" key depressed. In Windows, right-clicking anywhere on the JMOL image, or using either mouse button to click on the "JMOL" in the lower right corner, will generate a pop-up menu that provides many options for changing the view. To restore the original view, reload the page in the browser. Please note that you may need to move the JMOL interactive versions of the images to orient them the same as the static images.

Reference

  1. Jmol: An open-source Java viewer for chemical structures in 3D. http://www.jmol.org/.

Citation: O. Vadas, J. E. Burke, X. Zhang, A. Berndt, R. L Williams, Structural Basis for Activation and Inhibition of Class I Phosphoinositide 3-Kinases. Sci. Signal. 4, re2 (2011).

© 2011 American Association for the Advancement of Science


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