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Sci. Signal., 6 December 2011
[DOI: 10.1126/scisignal.2001637]

Supplementary Materials for:

PDLIM2 Inhibits T Helper 17 Cell Development and Granulomatous Inflammation Through Degradation of STAT3

Takashi Tanaka,* Yu Yamamoto, Ryuta Muromoto, Osamu Ikeda, Yuichi Sekine, Michael J. Grusby, Tsuneyasu Kaisho, Tadashi Matsuda*

*To whom correspondence should be addressed. E-mail: ttanaka{at}rcai.riken.jp (T.T.); tmatsuda{at}pharm.hokudai.ac.jp (T.M.)

This PDF file includes:

  • Fig. S1. PDLIM2 in T helper cell subsets.
  • Fig. S2. P. acnes–induced granuloma formation in Il-6– and Pdlim2-deficient mice.
  • Fig. S3. Enhanced P. acnes–induced IL-6 production by Pdlim2–/– dendritic cells.
  • Fig. S4. IL-6 induces tyrosine phosphorylation of STAT3, but not STAT1.
  • Fig. S5. Reduction in Pdlim2 mRNA abundance by PDLIM2-specific siRNA.

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Technical Details

Format: Adobe Acrobat PDF

Size: 340 KB


Citation: T. Tanaka, Y. Yamamoto, R. Muromoto, O. Ikeda, Y. Sekine, M. J. Grusby, T. Kaisho, T. Matsuda, PDLIM2 Inhibits T Helper 17 Cell Development and Granulomatous Inflammation Through Degradation of STAT3. Sci. Signal. 4, ra85 (2011).

© 2011 American Association for the Advancement of Science


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