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Sci. Signal., 3 January 2012
[DOI: 10.1126/scisignal.2001906]

Supplementary Materials for:

Inhibition of PP1 Phosphatase Activity by HBx: A Mechanism for the Activation of Hepatitis B Virus Transcription

Delphine Cougot, Eric Allemand, Lise Rivière, Shirine Benhenda, Karine Duroure, Florence Levillayer, Christian Muchardt, Marie-Annick Buendia, Christine Neuveut*

*To whom correspondence should be addressed. E-mail: christine.neuveut{at}pasteur.fr

This PDF file includes:

  • Fig. S1. Analysis of integrated HBV DNA and cccDNA in HepAD38 cells.
  • Fig. S2. Role of CREB in HBV DNA transcription.
  • Fig. S3. HBx prolongs CREB phosphorylation in HepG2 cells.
  • Fig. S4. HBx interacts with PP1 and HDAC1.
  • Fig. S5. Endogenous PP1 elutes with HDAC1 and HA-HBx in high–molecular weight fractions.
  • Fig. S6. The C-terminal region of HBx interacts with PP1 and is required for prolongation of CREB phosphorylation.
  • Fig. S7. Analysis of His-PP1α elution and HA-HBx abundance by Western blot.

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Technical Details

Format: Adobe Acrobat PDF

Size: 497 KB

Citation: D. Cougot, E. Allemand, L. Rivière, S. Benhenda, K. Duroure, F. Levillayer, C. Muchardt, M.-A. Buendia, C. Neuveut, Inhibition of PP1 Phosphatase Activity by HBx: A Mechanism for the Activation of Hepatitis B Virus Transcription. Sci. Signal. 5, ra1 (2012).

© 2012 American Association for the Advancement of Science

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