Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. Signal., 12 June 2012
[DOI: 10.1126/scisignal.2002790]

Supplementary Materials for:

The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis

Agnes Roczniak-Ferguson, Constance S. Petit, Florian Froehlich, Sharon Qian, Jennifer Ky, Brittany Angarola, Tobias C. Walther, Shawn M. Ferguson*

*To whom correspondence should be addressed. E-mail: shawn.ferguson{at}yale.edu

This PDF file includes:

  • Fig. S1. Regulation of TFEB localization by lysosomal status.
  • Fig. S2. 14-3-3 proteins are major binding partners of TFEB.
  • Fig. S3. Relationship between TFEB, mTOR, and lysosomes.
  • Fig. S4. MITF and TFE3 localization is sensitive to lysosome status.
  • Movie S1 legend

[Download PDF]

Technical Details

Format: Adobe Acrobat PDF

Size: 933 KB

Other Supplementary Material for this manuscript includes the following:

  • Movie S1 (.mov format). Time-lapse imaging of TFEB-GFP.

Technical Details

Format: Quicktime Movie

Size: 1.88 MB


Citation: A. Roczniak-Ferguson, C. S. Petit, F. Froehlich, S. Qian, J. Ky, B. Angarola, T. C. Walther, S. M. Ferguson, The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis. Sci. Signal. 5, ra42 (2012).

© 2012 American Association for the Advancement of Science


To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882