Microtubules Underlie Dysfunction in Duchenne Muscular Dystrophy

Ramzi J. Khairallah, Guoli Shi, Francesca Sbrana, Benjamin L. Prosser, Carlos Borroto, Mark J. Mazaitis, Eric P. Hoffman, Anup Mahurkar, Fredrick Sachs, Yezhou Sun, Yi-Wen Chen, Roberto Raiteri, W. Jonathan Lederer, Susan G. Dorsey,* Christopher W. Ward*

*To whom correspondence should be addressed. E-mail: ward{at}son.umaryland.edu (C.W.W.); sdorsey{at}son.umaryland.edu (S.G.D.)

This PDF file includes:

• Fig. S1. MuST setup.
• Fig. S2. Acute stretch results in a transient increase in X-ROS.
• Fig. S3. X-ROS signaling in dystrophic muscle fibers.
• Fig. S4. Macrophage infiltration in wild-type and mdx muscle.
• Fig. S5. Binary representation of fluorescent immunolabeling images of α-tubulin.
• Fig. S6. X-ROS and microtubules as the molecular basis of dysfunction in DMD.
• Fig. S7. Regression plot of RNA-seq and microarray data demonstrates good correlation between the two sample sets.
• Table S1. Demographic and phenotype data for normal controls and DMD cases for RNA-seq.

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Other Supplementary Material for this manuscript includes the following:

• Table S2. Microarray and RNA-seq analysis of normal and DMD skeletal muscle (text and Excel files in a ZIP archive).

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© 2012 American Association for the Advancement of Science