Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Sci. Signal., 14 August 2012
[DOI: 10.1126/scisignal.2002941]

Supplementary Materials for:

Interference with the PTEN-MAST2 Interaction by a Viral Protein Leads to Cellular Relocalization of PTEN

Elouan Terrien, Alain Chaffotte, Mireille Lafage, Zakir Khan, Christophe Préhaud, Florence Cordier, Catherine Simenel, Muriel Delepierre, Henri Buc, Monique Lafon,* Nicolas Wolff*

*To whom correspondence should be addressed. E-mail: monique.lafon{at}pasteur.fr (M.L.); nicolas.wolff{at}pasteur.fr (N.W.)

This PDF file includes:

  • Fig. S1. Intermolecular NOE spectra of MAST2-PDZ in complex with PTEN13-Cter.
  • Fig. S2. Cyto13-att disrupts the MAST2-PDZ/PTEN13-Cter complex in vitro.
  • Fig. S3. Differences in MAST2-PDZ amide proton chemical shifts between MAST2-PDZ/Cyto13-att and MAST2-PDZ/Cyto13-vir complexes.
  • Fig. S4. Intermolecular NOE spectra of MAST2-PDZ in complex with Cyto13-att.
  • Fig. S5. Dissociation constant of the MAST2-PDZ dimer measured by analytical ultracentrifugation at various protein concentrations.
  • Fig. S6. PTEN localization in human neuronal cells after intracellular delivery of a FITC-conjugated TAT–PTEN13-Cter.
  • Table S1. Statistical analysis of MAST2-PDZ/PTEN13-Cter and MAST2-PDZ/Cyto13-att NMR structures.
  • Reference

[Download PDF]

Technical Details

Format: Adobe Acrobat PDF

Size: 2.67 MB


Citation: E. Terrien, A. Chaffotte, M. Lafage, Z. Khan, C. Préhaud, F. Cordier, C. Simenel, M. Delepierre, H. Buc, M. Lafon, N. Wolff, Interference with the PTEN-MAST2 Interaction by a Viral Protein Leads to Cellular Relocalization of PTEN. Sci. Signal. 5, ra58 (2012).

© 2012 American Association for the Advancement of Science


To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882