Hedgehog-Stimulated Chemotaxis Is Mediated by Smoothened Located Outside the Primary Cilium

Maarten F. Bijlsma, Helene Damhofer, Henk Roelink*

*To whom correspondence should be addressed. E-mail: roelink{at}berkeley.edu

This PDF file includes:

• Fig. S1. Smo mutants fail to localize to the primary cilium.
• Fig. S2. Rab11 functions in the trafficking of Smo to the primary cilium.
• Fig. S3. Activating mutations in Smo do not rescue the transcriptional response phenotype or ciliary localization defect of SmoΔCLD.
• Fig. S4. Activation of nonciliary Smo results in activation of Src.
• Fig. S5. SmoWT and SmoΔCLD are expressed at similar amounts after transfection of Smo^+/– ES cells.
  

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© 2012 American Association for the Advancement of Science