The Membrane-Bound Enzyme CD38 Exists in Two Opposing Orientations

Yong Juan Zhao, Connie Mo Ching Lam, Hon Cheung Lee*

*To whom correspondence should be addressed. E-mail: leehc{at}hku.hk

This PDF file includes:

• Fig. S1. Validation of the monoclonal N-term antibody.
• Fig. S2. Validation of the polyclonal N-term antibody.
• Fig. S3. The polyclonal N-term antibody demonstrated the presence of type III CD38 in RA-treated HL-60 cells.
• Fig. S4. Detection of both forms of CD38 on the surface of IFN-γ–treated monocytes.
• Fig. S5. Immunostaining of human PBMCs with the C-term antibody against CD38.
• Fig. S6. The mutCD38 protein is biologically active.

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© 2012 American Association for the Advancement of Science