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Sci. Signal., 9 October 2012
[DOI: 10.1126/scisignal.2003212]

Supplementary Materials for:

Interferon-Induced SCYL2 Limits Release of HIV-1 by Triggering PP2A-Mediated Dephosphorylation of the Viral Protein Vpu

Kei Miyakawa, Tatsuya Sawasaki, Satoko Matsunaga, Andrey Tokarev, Gary Quinn, Hirokazu Kimura, Masako Nomaguchi, Akio Adachi, Naoki Yamamoto, John Guatelli, Akihide Ryo*

*To whom correspondence should be addressed. E-mail: aryo{at}yokohama-cu.ac.jp

This PDF file includes:

  • Fig. S1. Schematic representation of the initial screening method.
  • Fig. S2. The CKII inhibitor DRB phenocopies the effect of increased SCYL2 abundance.
  • Fig. S3. SCYL2 fails to inhibit SIVGSN Vpu–induced counteraction of BST2.
  • Fig. S4. SCYL2 inhibits Vpu function through a phosphorylation-dependent mechanism.

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Technical Details

Format: Adobe Acrobat PDF

Size: 674 KB


Citation: K. Miyakawa, T. Sawasaki, S. Matsunaga, A. Tokarev, G. Quinn, H. Kimura, M. Nomaguchi, A. Adachi, N. Yamamoto, J. Guatelli, A. Ryo, Interferon-Induced SCYL2 Limits Release of HIV-1 by Triggering PP2A-Mediated Dephosphorylation of the Viral Protein Vpu. Sci. Signal. 5, ra73 (2012).

© 2012 American Association for the Advancement of Science


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