Lack of the Phosphatase PTPN22 Increases Adhesion of Murine Regulatory T Cells to Improve Their Immunosuppressive Function

Rebecca J. Brownlie, Lisa A. Miosge, Demetrios Vassilakos, Lena M. Svensson, Andrew Cope, Rose Zamoyska*

*To whom correspondence should be addressed. E-mail: rose.zamoyska{at}ed.ac.uk

This PDF file includes:

• Fig. S1. Generation of a conditional allele of Ptpn22.
• Fig. S2. Normal thymocyte differentiation in Ptpn22^–/– mice.
• Fig. S3. CD4⁺ and CD8⁺ effector/memory cells are increased in number in Ptpn22^–/– mice.
• Fig. S4. Deficiency in PTPN22 results in increased total serum Ig concentrations.
• Fig. S5. Ptpn22^–/+ T_regs have an intermediate phenotype between those of wild-type and Ptpn22^–/– T_regs.
• Fig. S6. TCR signaling is enhanced in Ptpn22^–/– effector T cells.
• Table S1. Ptpn22^–/– T_regs have an activated phenotype.

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© 2012 American Association for the Advancement of Science