IGFBP7 Binds to the IGF-1 Receptor and Blocks Its Activation by Insulin-Like Growth Factors

Valentina Evdokimova, Cristina E. Tognon, Tania Benatar, Wenyi Yang, Konstantin Krutikov, Michael Pollak, Poul H. B. Sorensen, Arun Seth*

*To whom correspondence should be addressed. E-mail: arun.seth{at}utoronto.ca

This PDF file includes:

• Fig. S1. IGFBP7 does not interfere with activation of the IGF1R or INSR pathways when added simultaneously with their cognate ligands.
• Fig. S2. Pretreatment with IGFBP7 or its ectopic expression in cancer cell lines inhibits IGF-1–mediated activation of IGF1R.
• Fig. S3. Plasma membrane localization of IGFBP7 in treated or transfected cell lines.
• Fig. S4. Full-length but not the truncated form of IGFBP7 induces apoptosis in the absence of IGF-1.

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© 2012 American Association for the Advancement of Science