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Science 314 (5799): 602-603

Copyright © 2006 by the American Association for the Advancement of Science

Avoiding Collateral Damage in Alzheimer's Disease Treatment

Charles Glabe

Although beta-secretase has been considered a relatively harmless target for drugs against Alzheimer's disease, such drugs may damage nearby nerves.

The author is in the Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA. E-mail: cglabe{at}

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882