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Science 329 (5997): 1289-1290

Copyright © 2010 by the American Association for the Advancement of Science

Cell Biology

Septins at the Nexus

Yves Barral

Eukaryotic cells exist in a wide variety of shapes and functions. A source of variability is the appendages that cells form on their surfaces, such as the spines and axon that a neuron extends, the motile flagella of sperm and protists, and the beating cilia that many animal cells bear. These appendages constantly exchange material and information with the cell body from which they project, while maintaining their individuality. How they form and maintain themselves has intrigued scientists for almost a century. A study by Kim et al. (1) on page 1337 of this issue, and another by Hu et al. (2), report how proteins called septins contribute to the formation and maintenance of vertebrate cilia.

Institute of Biochemistry, ETH Zurich, 8093 Zurich, Switzerland.

E-mail: yves.barral{at}

Endosomal transport of septin mRNA and protein indicates local translation on endosomes and is required for correct septin filamentation.
S. Baumann, J. Konig, J. Koepke, and M. Feldbrugge (2014)
EMBO Rep. 15, 94-102
   Abstract »    Full Text »    PDF »
The Extracellular Signal-Regulated Kinase 3 (Mitogen-Activated Protein Kinase 6 [MAPK6])-MAPK-Activated Protein Kinase 5 Signaling Complex Regulates Septin Function and Dendrite Morphology.
F. Brand, S. Schumacher, S. Kant, M. B. Menon, R. Simon, B. Turgeon, S. Britsch, S. Meloche, M. Gaestel, and A. Kotlyarov (2012)
Mol. Cell. Biol. 32, 2467-2478
   Abstract »    Full Text »    PDF »

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