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Science 330 (6001): 183-184

Copyright © 2010 by the American Association for the Advancement of Science

Molecular Biology

Surfing Chromosomes (and Survivin)

Andrea Musacchio

Mothers are generally inclined to provide each of their offspring with similar opportunities. Even a mother cell abides by providing her daughters with an equal dowry of chromosomes. Diversions from fairness create imbalances in chromosome numbers that affect cell viability and are associated with tumor formation, infertility, and birth defects. Three papers in this issue—by Yamagishi et al. on page 239 (1), Wang et al. on page 231 (2), and Kelly et al. on page 235 (3)—describe how an enzyme (Aurora B protein kinase) that is essential for accurate chromosome inheritance is recruited to chromosomes that are poised to segregate into daughter cells.

Department of Experimental Oncology, European Institute of Oncology, Via Adamello 16, I-20139 Milan, Italy.

E-mail: andrea.musacchio{at}

Chk2 Phosphorylation of Survivin-{Delta}Ex3 Contributes to a DNA Damage-Sensing Checkpoint in Cancer.
A. Lopergolo, M. Tavecchio, S. Lisanti, J. C. Ghosh, T. Dohi, A. Faversani, V. Vaira, S. Bosari, N. Tanigawa, D. Delia, et al. (2012)
Cancer Res. 72, 3251-3259
   Abstract »    Full Text »    PDF »
Expression patterns of Aurora A and B kinases, Ki-67 and the estrogen and progesterone receptors determined using an endometriosis tissue microarray model.
A. Calcagno, T. Grassi, L. Mariuzzi, S. Marzinotto, A. P. Londero, M. Orsaria, C. A. Beltrami, and D. Marchesoni (2011)
Hum. Reprod. 26, 2731-2741
   Abstract »    Full Text »    PDF »
Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivation.
R. M. Ricke, K. B. Jeganathan, and J. M. van Deursen (2011)
J. Cell Biol. 193, 1049-1064
   Abstract »    Full Text »    PDF »
Developmental Control of Apoptosis by the Immunophilin Aryl Hydrocarbon Receptor-interacting Protein (AIP) Involves Mitochondrial Import of the Survivin Protein.
B. H. Kang, F. Xia, R. Pop, T. Dohi, M. Socolovsky, and D. C. Altieri (2011)
J. Biol. Chem. 286, 16758-16767
   Abstract »    Full Text »    PDF »

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