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Science 330 (6010): 1488-1490

Copyright © 2010 by the American Association for the Advancement of Science

First-Class Control of HIV-1

Andrew J. McMichael1, and E. Yvonne Jones2

The role of infectious disease in driving human genetic variations (polymorphisms) was first clearly espoused by J. B. S. Haldane in 1949 (1). Once the major histocompatibility complex (MHC) was established as the most polymorphic mammalian genetic system, searches began for human MHC [or human leukocyte antigen (HLA)] associations with infectious disease resistance. Such findings have been rare, though, possibly because susceptibility genes have been deselected over evolution. But the appearance of completely new infections caused by viruses, such as HIV-1, has opened opportunities to look at such selection in the MHC as it happens. On page 1551 of this issue, the International HIV Controllers Study (2), demonstrates the central role of HLA class I in controlling HIV-1 infection.

1 Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OS3 9DS, UK.
2 Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.

E-mail: andrew.mcmichael{at}; yvonne{at}

The Same Major Histocompatibility Complex Polymorphism Involved in Control of HIV Influences Peptide Binding in the Mouse H-2Ld System.
S. Narayanan and D. M. Kranz (2013)
J. Biol. Chem. 288, 31784-31794
   Abstract »    Full Text »    PDF »
Pegylated Interferon Alfa-2a Monotherapy Results in Suppression of HIV Type 1 Replication and Decreased Cell-Associated HIV DNA Integration.
L. Azzoni, A. S. Foulkes, E. Papasavvas, A. M. Mexas, K. M. Lynn, K. Mounzer, P. Tebas, J. M. Jacobson, I. Frank, M. P. Busch, et al. (2013)
The Journal of Infectious Disease 207, 213-222
   Abstract »    Full Text »    PDF »

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