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Science 331 (6019): 863-864

Copyright © 2011 by the American Association for the Advancement of Science

A Hand to Support the Implantation Window

Sylvia C. Hewitt, and Kenneth S. Korach

Reproduction in mammals is coordinated by an intricate sequence of events and signals that culminate in implantation of the embryo in the uterus (13). To succeed, these signals must be produced at the correct time, in the proper place, and in the amounts needed, and must be received by the appropriate targets. Perturbation of any of these factors can prevent establishment of pregnancy, resulting in infertility. On page 912 of this issue, Li et al. (4) show that the transcription factor Hand2 regulates signals that establish conditions in the mammalian uterus to support pregnancy.

National Institute of Environmental Health Science, National Institutes of Health, Research Triangle Park, NC 27709, USA.

E-mail: korach{at}

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Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882