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Science 331 (6019): 869-870

Copyright © 2011 by the American Association for the Advancement of Science

Creating Stable Memories

J. David Sweatt

Social animals with a keen sense of smell, such as rats, can teach each other about the safety of new foods by a practice called social transmission of food preference (STFP). In this olfactory learning paradigm, a rat that has just eaten can familiarize another rat with the taste odor of a new food by allowing the naïve rat to sniff its breath. The naïve rat apparently infers that the novel food is safe to eat because another rat has eaten it, and exhibits greatly diminished fear of the new food at first exposure. On page 924 of this issue, Lesburguéres et al. (1) describe their discovery of two fascinating aspects of this form of long-term memory: Specific neurons or synapses in the cerebral cortex are specifically "tagged" and thereby allocated to participate in a memory for a particular food odor, and this process involves epigenetic molecular mechanisms.

Department of Neurobiology and Evelyn F. McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

E-mail: dsweatt{at}nrc.uab.edu



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