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Science 331 (6021): 1145-1146

Copyright © 2011 by the American Association for the Advancement of Science

New Epigenetic Drivers of Cancers

Simon J. Elsässer, C. David Allis, Peter W. Lewis

Exome sequencing—the targeted sequencing of all protein-coding regions in the human genome—now offers an unprecedented opportunity for systematic, genome-wide discovery of somatic mutations in tumor tissue. On page 1199 of this issue, Jiao et al. (1) have applied this pioneering technique to identify common genetic mutations underlying pancreatic neuroendocrine tumors (PanNETs), a class of tumors that frequently arise from pancreatic islet cells. This report adds to a growing number of studies that use exome sequencing to explore cancers with unknown or poorly understood genetic etiology (28).

Laboratory of Chromatin Biology and Epigenetics, Rockefeller University, New York, NY 10065, USA.

E-mail: plewis{at}

Where are we now? And where are we going? A report from the Accelerate Brain Cancer Cure (ABC2) Low-grade Glioma Research Workshop.
J. T. Huse, M. Wallace, K. D. Aldape, M. S. Berger, C. Bettegowda, D. J. Brat, D. P. Cahill, T. Cloughesy, D. A. Haas-Kogan, M. Marra, et al. (2014)
Neuro Oncology 16, 173-178
   Abstract »    Full Text »    PDF »
CR Cistrome: a ChIP-Seq database for chromatin regulators and histone modification linkages in human and mouse.
Q. Wang, J. Huang, H. Sun, J. Liu, J. Wang, Q. Wang, Q. Qin, S. Mei, C. Zhao, X. Yang, et al. (2014)
Nucleic Acids Res. 42, D450-D458
   Abstract »    Full Text »    PDF »
Molecular Pathogenesis of Neuroendocrine Tumors: Implications for Current and Future Therapeutic Approaches.
K. Oberg, O. Casanovas, J. P. Castano, D. Chung, G. Delle Fave, P. Denefle, P. Harris, M. S. Khan, M. H. Kulke, A. Scarpa, et al. (2013)
Clin. Cancer Res. 19, 2842-2849
   Abstract »    Full Text »    PDF »
Inhibition of PRC2 Activity by a Gain-of-Function H3 Mutation Found in Pediatric Glioblastoma.
P. W. Lewis, M. M. Muller, M. S. Koletsky, F. Cordero, S. Lin, L. A. Banaszynski, B. A. Garcia, T. W. Muir, O. J. Becher, and C. D. Allis (2013)
Science 340, 857-861
   Abstract »    Full Text »    PDF »
Role of ATRX in chromatin structure and function: implications for chromosome instability and human disease.
R. De La Fuente, C. Baumann, and M. M. Viveiros (2011)
Reproduction 142, 221-234
   Abstract »    Full Text »    PDF »

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