Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Logo for

Science 331 (6022): 1271-1272

Copyright © 2011 by the American Association for the Advancement of Science

Listeria Unwinds Host DNA

John R. Rohde

Interferons (IFNs) are released by mammalian cells upon attack by microbial pathogens, alerting neighboring cells to prepare a defense that includes the activation of so-called IFN-stimulated genes. Although this response nearly always limits viral replication, its role during bacterial infection has not been clear. In some cases, the IFN response accelerates bacteria clearance, but in other cases, it results in a more severe disease (1, 2). The latter is true for Listeria monocytogenes, the bacterium that causes a range of human illnesses, from gastroenteritis to fatal meningitis. On page 1319 of this issue, Lebreton et al. (3) identify a new virulence factor, LntA, secreted by L. monocytogenes, that controls the expression of IFN-stimulated genes. The mechanism allows the bacterium to govern both the induction and repression of the host cell immune response, perhaps to optimize conditions for specific stages of infection or colonization of specific tissues.

Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia 75015, Canada.

E-mail: john.rohde{at}

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882