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Science 331 (6022): 1275-1276

Copyright © 2011 by the American Association for the Advancement of Science

Crise de Foie, Redux?

David D. Moore

Disruption of circadian rhythms due to rotating shift work affects up to 20% of the workforce in industrialized countries, resulting in a nearly twofold greater risk of developing the metabolic syndrome in this population (1). The role of the circadian clock in maintaining metabolic balance is confirmed by the obesity, insulin resistance, and fatty liver observed in mice with mutations in clock components (2). Fatty liver (steatosis, or nonalcoholic fatty liver disease) is a major driver of metabolic dysregulation (3). On page 1315 of this issue, Feng et al. (4) identify a molecular mechanism that links circadian disruption and fatty liver.

Department of Molecular and Cellular Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.

E-mail: moore{at}

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