|
|
Copyright © 2011 by the American Association for the Advancement of Science
An Innate Role for IL-17Margarita Dominguez-Villar, and David A. Hafler Insight into the functional role of a particular component of the immune system, such as a cell type, cytokine, or constituent of a signaling pathway, can be gleaned from diverse human genetic mutations that have naturally occurred in critical immune system processes. For example, immune dysregulation polyendocrinopathy enteropathy X-linked syndrome is an autoimmune disease that was determined to be secondary to dysregulation of a subset of regulatory immune cells (CD4 subset of T cells) caused by mutations in the FOXP3 gene. This discovery identified the transcription factor FOXP3 in controlling normal immune responses and raised the issue of defects in regulatory T cells in more common human autoimmune disorders (1). On page 65 of this issue, Puel et al. (2) report tracing an abnormal immune response to infection with the common fungus Candida albicans to mutations in components of a signaling pathway involving the cytokine interleukin-17 (IL-17).
Department of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA. E-mail: david.hafler{at}yale.ed
The editors suggest the following Related Resources on Science sites:In Science Magazine
In Science Signaling
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
|
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882
News | Science Journals | Careers | Blogs and Communities | Multimedia | Collections | Help | Site Map | RSS
Subscribe | Feedback | Privacy / Legal | About Us | Advertise With Us | Contact Us
© 2011 American Association for the Advancement of Science. All Rights Reserved.
AAAS is a partner of HINARI, AGORA, OARE, PatientInform, CrossRef, and COUNTER.
You have reached the bottom of the page. Back to top