Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Logo for

Science 332 (6028): 427-428

Copyright © 2011 by the American Association for the Advancement of Science

Progranulin Resolves Inflammation

Hao Wu1, and Richard M. Siegel2

The cytokine tumor necrosis factor α (TNFα) is a major driver of rheumatoid arthritis and related inflammatory diseases. Therapeutic agents that block TNFα or mimic a soluble receptor for the cytokine are effective in these diseases, but whether other endogenous modulators of TNFα action exist that could be targets for therapeutic intervention is not clear. On page 478 of this issue, Tang et al. (1) show that progranulin, a secreted molecule with some cytokine-like properties, binds to TNF receptors and limits the action of TNFα in inflammatory arthritis.

1 Department of Biochemistry, Weill Cornell Medical College, New York, NY 10065, USA.
2 National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20814, USA.

E-mail: siegelr{at}

Deletion of progranulin exacerbates atherosclerosis in ApoE knockout mice.
R. Kawase, T. Ohama, A. Matsuyama, T. Matsuwaki, T. Okada, T. Yamashita, M. Yuasa-Kawase, H. Nakaoka, K. Nakatani, M. Inagaki, et al. (2013)
Cardiovasc Res 100, 125-133
   Abstract »    Full Text »    PDF »
Insights into the role of progranulin in immunity, infection, and inflammation.
J. Jian, J. Konopka, and C. Liu (2013)
J. Leukoc. Biol. 93, 199-208
   Abstract »    Full Text »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882