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Science 334 (6058): 915-916

Copyright © 2011 by the American Association for the Advancement of Science

Antioxidant Strategies to Tolerate Antibiotics

Peter Belenky1, and James J. Collins1,2,3

In living organisms, aerobic metabolism produces toxic reactive oxygen species (ROS) (1). Life can thus be seen as a balance between metabolic rate and a cell's ability to detoxify ROS. This understanding has led to intense public interest and increased consumption of dietary antioxidants. Although the effectiveness of antioxidant supplements is not yet established, there is no doubt that eukaryotic and prokaryotic cells have developed efficient endogenous antioxidant mechanisms (1, 2). On pages 982 and 986 of this issue, Nguyen et al. (3) and Shatalin et al. (4) describe two such mechanisms that confer antibiotic tolerance in bacteria.

1 Howard Hughes Medical Institute, Department of Biomedical Engineering and Center for BioDynamics, Boston University, Boston, MA 02215, USA.
2 Boston University School of Medicine, Boston, MA 02118, USA.
3 Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.

E-mail: jcollins{at}engc.bu.edu


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
New Antibiotic Strategies.
Richard T. Ellison III, MD and Richard T. Ellison III, MD (2013)
Journal Watch 2011, ID201112210000005
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New Antibiotic Strategies.
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Journal Watch Infectious Diseases 2011, 5
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