Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Logo for

Science 334 (6058): 915-916

Copyright © 2011 by the American Association for the Advancement of Science

Antioxidant Strategies to Tolerate Antibiotics

Peter Belenky1, and James J. Collins1,2,3

In living organisms, aerobic metabolism produces toxic reactive oxygen species (ROS) (1). Life can thus be seen as a balance between metabolic rate and a cell's ability to detoxify ROS. This understanding has led to intense public interest and increased consumption of dietary antioxidants. Although the effectiveness of antioxidant supplements is not yet established, there is no doubt that eukaryotic and prokaryotic cells have developed efficient endogenous antioxidant mechanisms (1, 2). On pages 982 and 986 of this issue, Nguyen et al. (3) and Shatalin et al. (4) describe two such mechanisms that confer antibiotic tolerance in bacteria.

1 Howard Hughes Medical Institute, Department of Biomedical Engineering and Center for BioDynamics, Boston University, Boston, MA 02215, USA.
2 Boston University School of Medicine, Boston, MA 02118, USA.
3 Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.

E-mail: jcollins{at}

New Antibiotic Strategies.
Richard T. Ellison III, MD and Richard T. Ellison III, MD (2013)
Journal Watch 2011, ID201112210000005
   Full Text »
New Antibiotic Strategies.
Journal Watch Infectious Diseases 2011, 5
   Full Text »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882