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Science 335 (6069): 667-668

Copyright © 2012 by the American Association for the Advancement of Science

Remembering to Be Tolerant

June-Yong Lee, and Stephen C. Jameson

We avoid potentially lethal autoreactivity because our adaptive immune system ignores normal, healthy tissues. Although multiple mechanisms induce self-tolerance, it is less clear how tolerance is maintained. On page 723 in this issue, Schietinger et al. (1) report that self-specific T lymphocytes can be driven to transiently break tolerance, but revert back to the tolerant state, even in the absence of the relevant self-antigen. This suggests that a "memory" of tolerance restrains autoreactive lymphocytes.

Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55414, USA.

E-mail: james024{at}

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