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Sci. STKE, 27 June 2000
Vol. 2000, Issue 38, p. tw7
[DOI: 10.1126/scisignal.382000tw7]

EDITORS' CHOICE

Immunology Rac2 in Th1 Cells

Immune responses can be mediated by cells (cell-mediated immunity) or through circulating factors like antibodies (humoral immunity), depending on whether naive T cells differentiate into T helper 1 (Th1) or T helper 2 (Th2) cells. Li et al. report that the small guanosine triphosphatase Rac2 increased the expression of interferon {gamma} (IFN{gamma}), a cytokine that promotes T cell differentiation, and that it appeared to signal through the mitogen-activated protein kinase p38 and the transcription factor NF-{kappa}B.

Li, B., Yu, H. Zheng, W.-P., Voll, R., Na, S., Roberts, A.W., Williams, D.A., Davis, R.J., Ghosh, S., and Flavell, R.A. (2000) Role of the guanosine triphosphatase Rac2 in T helper 1 cell differentiation. Science 288: 2219-2222. [Abstract] [Full Text]

Citation: Rac2 in Th1 Cells. Sci. STKE 2000, tw7 (2000).

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