Sci. STKE, 12 September 2000
Stem Cells C'mon Back!
Useful as the oligodendrocyte precursor cells are to the central nervous system, given their ability to generate a steady supply of the cells that insulate neurons, it seems they can do even better. Kondo and Raff (see the news story by Vogel) now show that these limited-potential precursor cells can, with treatment by a series of external growth factors, be made to "back up" through the developmental cascade. The result is a source of stem cells with greater potential than the original that can form a variety of differentiated neuronal cell types.
Vogel, G. (2000) Brain cells turning over a new leaf. Science 289: 1666. [Full Text]
Citation: C'mon Back! Sci. STKE 2000, tw1 (2000).