Sci. STKE, 17 October 2000
Cell Motility Watching the Signals
How signaling molecules function is not only a matter of when but also a matter of where. Kraynov et al. demonstrate that activation of the small guanosine triphosphate-binding protein Rac1 can be visualized in real time in living cells. Activation of Rac1, known to induce actin-based morphological changes, was restricted to sites of actin polymerization, independent of overall intracellular Rac distribution. Thus, cells can produce distinct behaviors through specific distributions of activated Rac1.
Kraynov, V.S., Chamberlain, C., Bokoch, G.M., Schwartz, M.A., Slabaugh, S., and Hahn, K.M. (2000) Localized Rac activation dynamics visualized in living cells. Science 290: 333-337. [Full Text] [Abstract]
Citation: Watching the Signals. Sci. STKE 2000, tw2 (2000).
Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882