Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Sci. STKE, 21 August 2001
Vol. 2001, Issue 96, p. tw8
[DOI: 10.1126/scisignal.962001tw8]

EDITORS' CHOICE

Intracellular Movement Myosin-V Regulation

Myosin-V is a microtubule-based motor responsible for promoting organelle movements around the cell, particularly the movement of melanophores around melanocytes. During mitosis, the activity of myosin-V is decreased, probably by phosphorylation, as the microtubule machinery is co-opted into spindle assembly and membrane traffic shuts down. Karcher et al. (see the Perspective by Cheney and Rodriguez) describe the precise phosphorylation site that is present in the organelle-binding carboxyl terminal of the protein. The authors suggest that such phosphorylation to abrogate cargo binding may be used more generally.

R. L. Karcher, J. T. Roland, F. Zappacosta, M. J. Huddleston, R. S. Annan, S. A. Carr, V. I. Gelfand, Cell cycle regulation of myosin-V by calcium/calmodulin-dependent protein kinase II. Science 293, 1317-1320 (2001). [Abstract] [Full Text]

R. E. Cheney, O. C. Rodriguez, A switch to release the motor. Science 293, 1263-1264 (2001). [Full Text]

Citation: Myosin-V Regulation. Sci. STKE 2001, tw8 (2001).

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882