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Science 289 (5488): 2293-2294

Copyright © 2000 by the American Association for the Advancement of Science

BIOMEDICINE:
Protein Loss in Cancer Cachexia

Michael J. Tisdale

Muscle wasting (cachexia) is a debilitating syndrome that is common in AIDS and cancer patients. In his Perspective, Tisdale explores exciting new findings (Guttridge et al.) showing that the master transcription factor NF-kB decreases the expression of MyoD, a transcription factor involved in the differentiation of muscle stem cells in response to damage or wasting of skeletal muscle. This work opens up new therapeutic strategies for the treatment of this life-threatening syndrome.


The author is at the Pharmaceutical Sciences Research Institute, Aston University, Birmingham B4 7ET, UK.


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Thalidomide: Dual benefits in palliative medicine and oncology.
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American Journal of Hospice and Palliative Medicine 18, 347-351
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Resistance Exercise Training Attenuates Wasting of the Extensor Digitorum Longus Muscle in Mice Bearing the Colon-26 Adenocarcinoma.
S. Al-Majid and D. O. McCarthy (2001)
Biol Res Nurs 2, 155-166
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Cancer-Induced Fatigue and Skeletal Muscle Wasting: The Role of Exercise.
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Biol Res Nurs 2, 186-197
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