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Science 289 (5488): 2293-2294

Copyright © 2000 by the American Association for the Advancement of Science

Protein Loss in Cancer Cachexia

Michael J. Tisdale

Muscle wasting (cachexia) is a debilitating syndrome that is common in AIDS and cancer patients. In his Perspective, Tisdale explores exciting new findings (Guttridge et al.) showing that the master transcription factor NF-kB decreases the expression of MyoD, a transcription factor involved in the differentiation of muscle stem cells in response to damage or wasting of skeletal muscle. This work opens up new therapeutic strategies for the treatment of this life-threatening syndrome.

The author is at the Pharmaceutical Sciences Research Institute, Aston University, Birmingham B4 7ET, UK.

Association of Interleukin-10 Gene Polymorphism with Cachexia in Chinese Patients with Gastric Cancer.
F. Sun, Y. Sun, D. Zhang, J. Zhang, B. Song, and H. Zheng (2010)
Ann. Clin. Lab. Sci. 40, 149-155
   Abstract »    Full Text »    PDF »
Decreased Jun-D and myogenin expression in muscle wasting of human cachexia.
S. Ramamoorthy, M. Donohue, and M. Buck (2009)
Am J Physiol Endocrinol Metab 297, E392-E401
   Abstract »    Full Text »    PDF »
PPAR{gamma} inhibits NF-{kappa}B-dependent transcriptional activation in skeletal muscle.
A. H. V. Remels, R. C. J. Langen, H. R. Gosker, A. P. Russell, F. Spaapen, J. W. Voncken, P. Schrauwen, and A. M. W. J. Schols (2009)
Am J Physiol Endocrinol Metab 297, E174-E183
   Abstract »    Full Text »    PDF »
TNF-{alpha} acts via TNFR1 and muscle-derived oxidants to depress myofibrillar force in murine skeletal muscle.
B. J. Hardin, K. S. Campbell, J. D. Smith, S. Arbogast, J. Smith, J. S. Moylan, and M. B. Reid (2008)
J Appl Physiol 104, 694-699
   Abstract »    Full Text »    PDF »
Association of IL-6 Gene Polymorphisms with Cachexia Susceptibility and Survival Time of Patients with Pancreatic Cancer.
D. Zhang, Y. Zhou, L. Wu, S. Wang, H. Zheng, B. Yu, and J. Li (2008)
Ann. Clin. Lab. Sci. 38, 113-119
   Abstract »    Full Text »    PDF »
Experimental arthritis inhibits the insulin-like growth factor-I axis and induces muscle wasting through cyclooxygenase-2 activation.
M. Granado, A. I Martin, M{a} A. Villanua, and A. Lopez-Calderon (2007)
Am J Physiol Endocrinol Metab 292, E1656-E1665
   Abstract »    Full Text »    PDF »
Prevention of Cancer Cachexia by Pyrrolidine Dithiocarbamate (PDTC) in Colon 26 Tumor-Bearing Mice.
Y.-J. Nai, Z.-W. Jiang, Z.-M. Wang, N. Li, and J.-S. Li (2007)
JPEN J Parenter Enteral Nutr 31, 18-25
   Abstract »    Full Text »    PDF »
Tumour necrosis factor blockade did not prevent the increase of muscular muscle RING finger-1 and muscle atrophy F-box in arthritic rats.
M Granado, A I Martin, T Priego, A Lopez-Calderon, and M A Villanua (2006)
J. Endocrinol. 191, 319-326
   Abstract »    Full Text »    PDF »
Reduction of Skeletal Muscle Atrophy by a Proteasome Inhibitor in a Rat Model of Denervation.
B. C. Beehler, P. G. Sleph, L. Benmassaoud, and G. J. Grover (2006)
Experimental Biology and Medicine 231, 335-341
   Abstract »    Full Text »    PDF »
TNF-{alpha} acts via p38 MAPK to stimulate expression of the ubiquitin ligase atrogin1/MAFbx in skeletal muscle.
Y.-P. Li, Y. Chen, J. John, J. Moylan, B. Jin, D. L. Mann, and M. B. Reid (2005)
FASEB J 19, 362-370
   Abstract »    Full Text »    PDF »
Cytokine-induced Patterns of Gene Expression in Skeletal Muscle Tissue.
T. Alon, J. M. Friedman, and N. D. Socci (2003)
J. Biol. Chem. 278, 32324-32334
   Abstract »    Full Text »    PDF »
Effect of Fish Oil on Appetite and Other Symptoms in Patients With Advanced Cancer and Anorexia/Cachexia: A Double-Blind, Placebo-Controlled Study.
E. Bruera, F. Strasser, J. L. Palmer, J. Willey, K. Calder, G. Amyotte, and V. Baracos (2003)
J. Clin. Oncol. 21, 129-134
   Abstract »    Full Text »    PDF »
Altered expression of skeletal muscle myosin isoforms in cancer cachexia.
G. M. Diffee, K. Kalfas, S. Al-Majid, and D. O. McCarthy (2002)
Am J Physiol Cell Physiol 283, C1376-C1382
   Abstract »    Full Text »    PDF »
Molecular-Based Therapeutic Approaches in Treatment of Anorexia of Aging and Cancer Cachexia.
D. Hamerman (2002)
J Gerontol A Biol Sci Med Sci 57, M511-M518
   Abstract »    Full Text »    PDF »
Inhibition of Angiogenesis-driven Kaposi's Sarcoma Tumor Growth in Nude Mice by Oral N-Acetylcysteine.
A. Albini, M. Morini, F. D'Agostini, N. Ferrari, F. Campelli, G. Arena, D. M. Noonan, C. Pesce, and S. De Flora (2001)
Cancer Res. 61, 8171-8178
   Abstract »    Full Text »    PDF »
Thalidomide: Dual benefits in palliative medicine and oncology.
M. P. Davis and E. D. Dickerson (2001)
American Journal of Hospice and Palliative Medicine 18, 347-351
   Abstract »    PDF »
Resistance Exercise Training Attenuates Wasting of the Extensor Digitorum Longus Muscle in Mice Bearing the Colon-26 Adenocarcinoma.
S. Al-Majid and D. O. McCarthy (2001)
Biol Res Nurs 2, 155-166
   Abstract »    PDF »
Cancer-Induced Fatigue and Skeletal Muscle Wasting: The Role of Exercise.
S. Al-Majid and D. O. McCarthy (2001)
Biol Res Nurs 2, 186-197
   Abstract »    PDF »

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