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Science 295 (5553): 284-287

Copyright © 2002 by the American Association for the Advancement of Science

Also see the archival list of Science's Compass: Enhanced Perspectives

Enhanced: Integrating Interactomes

Mark Gerstein, Ning Lan, Ronald Jansen

In the postgenomic era, working out which proteins interact with each other will be important for finding out what each protein does. In their Perspective, Gerstein et al. describe new work (Tong et al.) that combines two completely different data sets to work out which yeast proteins interact and which peptide recognition domains are involved.

The authors are in the Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA. E-mail: mark.gerstein{at}

The impact of cellular networks on disease comorbidity.
J. Park, D.-S. Lee, N. A. Christakis, and A.-L. Barabasi (2014)
Mol Syst Biol 5, 262
   Abstract »    Full Text »    PDF »
Systems-level analyses identify extensive coupling among gene expression machines.
K. Maciag, S. J. Altschuler, M. D. Slack, N. J. Krogan, A. Emili, J. F. Greenblatt, T. Maniatis, and L. F. Wu (2014)
Mol Syst Biol 2, 2006.0003
   Abstract »    Full Text »    PDF »
FunCoup 3.0: database of genome-wide functional coupling networks.
T. Schmitt, C. Ogris, and E. L. L. Sonnhammer (2014)
Nucleic Acids Res. 42, D380-D388
   Abstract »    Full Text »    PDF »
Human Endoplasmic Reticulum Mannosidase I Is Subject to Regulated Proteolysis.
Y. Wu, D. J. Termine, M. T. Swulius, K. W. Moremen, and R. N. Sifers (2007)
J. Biol. Chem. 282, 4841-4849
   Abstract »    Full Text »    PDF »
Bacterial Postgenomics: the Promise and Peril of Systems Biology{triangledown}.
G. Suen, J. S. Jakobsen, B. S. Goldman, M. Singer, A. G. Garza, and R. D. Welch (2006)
J. Bacteriol. 188, 7999-8004
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Assessing the limits of genomic data integration for predicting protein networks.
L. J. Lu, Y. Xia, A. Paccanaro, H. Yu, and M. Gerstein (2005)
Genome Res. 15, 945-953
   Abstract »    Full Text »    PDF »
Lack of Myoglobin Causes a Switch in Cardiac Substrate Selection.
U. Flogel, T. Laussmann, A. Godecke, N. Abanador, M. Schafers, C. D. Fingas, S. Metzger, B. Levkau, C. Jacoby, and J. Schrader (2005)
Circ. Res. 96, e68-e75
   Abstract »    Full Text »    PDF »
From Gene Networks to Gene Function.
T. Schlitt, K. Palin, J. Rung, S. Dietmann, M. Lappe, E. Ukkonen, and A. Brazma (2003)
Genome Res. 13, 2568-2576
   Abstract »    Full Text »    PDF »
Protein complexes and functional modules in molecular networks.
V. Spirin and L. A. Mirny (2003)
PNAS 100, 12123-12128
   Abstract »    Full Text »    PDF »

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