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Sci. Signal., 18 September 2012
Vol. 5, Issue 242, p. rs6
Networking the DNA Damage Response
The protein-protein interaction domain BRCT is found in proteins that participate in the DNA damage response (DDR) and has been linked to cancer. A well-known BRCT domain–containing protein is the DDR protein BRCA1, encoded by a gene that is associated with breast cancer. Woods et al. performed systems analysis to identify proteins that interacted with BRCT domains in cells exposed to DNA damage. Bioinformatics analysis of the BRCT protein-protein interaction network revealed biological processes and protein complexes that integrate the DDR with cell cycle regulation and transcription. Because of the importance of BRCT domain–containing proteins in cancer, understanding the cellular response to DDR-inducing chemotherapy and radiation therapy can aid in the development of effective treatments.
Citation: N. T. Woods, R. D. Mesquita, M. Sweet, M. A. Carvalho, X. Li, Y. Liu, H. Nguyen, C. E. Thomas, E. S. Iversen, Jr., S. Marsillac, R. Karchin, J. Koomen, A. N. A. Monteiro, Charting the Landscape of Tandem BRCT Domain–Mediated Protein Interactions. Sci. Signal.5, rs6 (2012).
Jes Alexander, Daniel Lim, Brian A. Joughin, Björn Hegemann, James R. A. Hutchins, Tobias Ehrenberger, Frank Ivins, Fabio Sessa, Otto Hudecz, Erich A. Nigg, Andrew M. Fry, Andrea Musacchio, P. Todd Stukenberg, Karl Mechtler, Jan-Michael Peters, Stephen J. Smerdon, and Michael B. Yaffe (28 June 2011) Sci. Signal.4 (179), ra42.
[DOI: 10.1126/scisignal.2001796] |Editor's Summary »|Abstract »|Full Text »|PDF »|Supplementary Materials »