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Sci. Signal., 2 April 2013
Vol. 6, Issue 269, p. ra22
[DOI: 10.1126/scisignal.2003405]


Editor's Summary

Activating p53 with IMPK
The transcription factor p53 mediates cell death in response to cellular stress. Xu et al. found that the transcriptional activity of p53 was enhanced by inositol polyphosphate multikinase (IPMK). IPMK bound to p53 directly and stimulated its acetylation by the acetyltransferase p300. Loss of IPMK or disruption of the IPMK-p53 interaction decreased acetylation of both p53 and the promoters of its target genes, reduced the transcription of p53 target genes, and decreased p53-mediated apoptosis. Thus, IPMK functions as a transcriptional coactivator of p53.

Citation: R. Xu, N. Sen, B. D. Paul, A. M. Snowman, F. Rao, M. S. Vandiver, J. Xu, S. H. Snyder, Inositol Polyphosphate Multikinase Is a Coactivator of p53-Mediated Transcription and Cell Death. Sci. Signal. 6, ra22 (2013).

Read the Full Text

Activation of p53 Transcriptional Activity by SMRT: a Histone Deacetylase 3-Independent Function of a Transcriptional Corepressor.
A. K. Adikesavan, S. Karmakar, P. Pardo, L. Wang, S. Liu, W. Li, and C. L. Smith (2014)
Mol. Cell. Biol. 34, 1246-1261
   Abstract »    Full Text »    PDF »
Inositol polyphosphate multikinase is a coactivator for serum response factor-dependent induction of immediate early genes.
E. Kim, R. Tyagi, J.-Y. Lee, J. Park, Y.-r. Kim, J. Beon, P. Y. Chen, J. Y. Cha, S. H. Snyder, and S. Kim (2013)
PNAS 110, 19938-19943
   Abstract »    Full Text »    PDF »
Inositol polyphosphate multikinase is a transcriptional coactivator required for immediate early gene induction.
R. Xu, B. D. Paul, D. R. Smith, R. Tyagi, F. Rao, A. B. Khan, D. J. Blech, M. S. Vandiver, M. M. Harraz, P. Guha, et al. (2013)
PNAS 110, 16181-16186
   Abstract »    Full Text »    PDF »
Science Signaling Podcast: 2 April 2013.
R. Xu and A. M. VanHook (2013)
Science Signaling 6, pc9
   Abstract »    Full Text »

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