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Science 295 (5556): 807-808

Copyright © 2002 by the American Association for the Advancement of Science

Also see the archival list of Science's Compass: Enhanced Perspectives

TRANSCRIPTION:
Enhanced: Oxygen Sensing Gets a Second Wind

Richard K. Bruick and Steven L. McKnight

The recent discovery of molecules that mediate the hypoxia response pathway demonstrates that mammalian cells are supremely well adapted to dealing with conditions of low oxygen. In their Perspective, Bruick and McKnight detail new findings (Lando et al.) that describe an additional way in which the transcription factor HIF, a central player in the hypoxia response pathway, can be regulated.

The authors are in the Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard L3.124, Dallas, TX 75390-9152, USA. E-mail: bruick{at}biochem.swmed.edu, smckni{at}biochem.swmed.edu

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