Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
Also see the archival list of Science's Compass: Enhanced Perspectives
TRANSCRIPTION: Enhanced: Oxygen Sensing Gets a Second Wind
Richard K. Bruick and Steven L. McKnight
The recent discovery of molecules that mediate the hypoxia response pathway demonstrates that mammalian cells are supremely well adapted to dealing with conditions of low oxygen. In their Perspective, Bruick and McKnight detail new findings (Lando et al.) that describe an additional way in which the transcription factor HIF, a central player in the hypoxia response pathway, can be regulated.
The authors are in the Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard L3.124, Dallas, TX 75390-9152, USA. E-mail: bruick{at}biochem.swmed.edu, smckni{at}biochem.swmed.edu
The editors suggest the following Related Resources on Science sites:
In Science Magazine
REPORTS
David Lando, Daniel J. Peet, Dean A. Whelan, Jeffrey J. Gorman, and Murray L. Whitelaw (1 February 2002) Science295 (5556), 858.
[DOI: 10.1126/science.1068592] |Abstract »|Full Text »|PDF »|Supplemental Data »
G. Zhou, L. A. Dada, M. Wu, A. Kelly, H. Trejo, Q. Zhou, J. Varga, and J. I. Sznajder (2009)
Am J Physiol Lung Cell Mol Physiol
297, L1120-L1130
|Abstract »|Full Text »|PDF »
Increased prolyl 4-hydroxylase expression and differential regulation of hypoxia-inducible factors in the aged rat brain.
O. I. Ndubuizu, J. C. Chavez, and J. C. LaManna (2009)
Am J Physiol Regulatory Integrative Comp Physiol
297, R158-R165
|Abstract »|Full Text »|PDF »
Neuron-Specific Inactivation of the Hypoxia Inducible Factor 1{alpha} Increases Brain Injury in a Mouse Model of Transient Focal Cerebral Ischemia.
O. Baranova, L. F. Miranda, P. Pichiule, I. Dragatsis, R. S. Johnson, and J. C. Chavez (2007)
J. Neurosci.
27, 6320-6332
|Abstract »|Full Text »|PDF »
Glycogen Synthase Kinase 3 Phosphorylates Hypoxia-Inducible Factor 1{alpha} and Mediates Its Destabilization in a VHL-Independent Manner.
D. Flugel, A. Gorlach, C. Michiels, and T. Kietzmann (2007)
Mol. Cell. Biol.
27, 3253-3265
|Abstract »|Full Text »|PDF »
Identification of MAPK Phosphorylation Sites and Their Role in the Localization and Activity of Hypoxia-inducible Factor-1{alpha}.
I. Mylonis, G. Chachami, M. Samiotaki, G. Panayotou, E. Paraskeva, A. Kalousi, E. Georgatsou, S. Bonanou, and G. Simos (2006)
J. Biol. Chem.
281, 33095-33106
|Abstract »|Full Text »|PDF »
Genetic Organization and Hypoxic Activation of the Kaposi's Sarcoma-Associated Herpesvirus ORF34-37 Gene Cluster.
M. Haque, V. Wang, D. A. Davis, Z.-M. Zheng, and R. Yarchoan (2006)
J. Virol.
80, 7037-7051
|Abstract »|Full Text »|PDF »
Proteomic Analysis of Colorectal Cancer Reveals Alterations in Metabolic Pathways: Mechanism of Tumorigenesis.
X. Bi, Q. Lin, T. W. Foo, S. Joshi, T. You, H.-M. Shen, C. N. Ong, P. Y. Cheah, K. W. Eu, and C.-L. Hew (2006)
Mol. Cell. Proteomics
5, 1119-1130
|Abstract »|Full Text »|PDF »
DNA and mRNA elements with complementary responses to hemin, antioxidant inducers, and iron control ferritin-L expression.
A Mechanism of Oxygen Sensing in Yeast: MULTIPLE OXYGEN-RESPONSIVE STEPS IN THE HEME BIOSYNTHETIC PATHWAY AFFECT Hap1 ACTIVITY.
T. Hon, A. Dodd, R. Dirmeier, N. Gorman, P. R. Sinclair, L. Zhang, and R. O. Poyton (2003)
J. Biol. Chem.
278, 50771-50780
|Abstract »|Full Text »|PDF »
Hepatitis B Virus X Protein Enhances Transcriptional Activity of Hypoxia-inducible Factor-1{alpha} through Activation of Mitogen-activated Protein Kinase Pathway.
Y.-G. Yoo, S. H. Oh, E. S. Park, H. Cho, N. Lee, H. Park, D. K. Kim, D.-Y. Yu, J. K. Seong, and M.-O. Lee (2003)
J. Biol. Chem.
278, 39076-39084
|Abstract »|Full Text »|PDF »
Defective Brain Development in Mice Lacking the Hif-1{alpha} Gene in Neural Cells.
S. Tomita, M. Ueno, M. Sakamoto, Y. Kitahama, M. Ueki, N. Maekawa, H. Sakamoto, M. Gassmann, R. Kageyama, N. Ueda, et al. (2003)
Mol. Cell. Biol.
23, 6739-6749
|Abstract »|Full Text »|PDF »
USF1 and USF2 Mediate Inhibition of Human Trophoblast Differentiation and CYP19 Gene Expression by Mash-2 and Hypoxia.
In Silico Pattern-Based Analysis of the Human Cytomegalovirus Genome.
I. Rigoutsos, J. Novotny, T. Huynh, S. T. Chin-Bow, L. Parida, D. Platt, D. Coleman, and T. Shenk (2003)
J. Virol.
77, 4326-4344
|Abstract »|Full Text »|PDF »
Podocyte Expression of Hypoxia-Inducible Factor (HIF)-1 and HIF-2 during Glomerular Development.
P. B. Freeburg, B. Robert, P. L. St. John, and D. R. Abrahamson (2003)
J. Am. Soc. Nephrol.
14, 927-938
|Abstract »|Full Text »|PDF »
Regulation of Hypoxia-Inducible Factor 1{alpha} Expression and Function by the Mammalian Target of Rapamycin.
C. C. Hudson, M. Liu, G. G. Chiang, D. M. Otterness, D. C. Loomis, F. Kaper, A. J. Giaccia, and R. T. Abraham (2002)
Mol. Cell. Biol.
22, 7004-7014
|Abstract »|Full Text »|PDF »