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Science 289 (5487): 2066-2067

Copyright © 2000 by the American Association for the Advancement of Science

Also see the archival list of Science's Compass: Enhanced Perspectives

BIOMEDICINE:
Enhanced: Staying Slim with Insulin in Mind

Michael W. Schwartz

Striking the delicate balance between energy intake in the form of food and energy expenditure in the form of metabolic activity keeps the body extremely busy. As Schwartz explains in his enlightening Perspective, the finding that insulin signals the brain to promote weight loss (Brüning et al.) flies in the face of the notion that insulin is involved solely in glucose storage, its conversion to fat, and weight gain.

The author is in the Division of Metabolism, Endocrinology and Nutrition, University of Washington, Seattle, WA 98105, USA. E-mail: mschwart{at}u.washington.edu

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Awake Intranasal Insulin Delivery Modifies Protein Complexes and Alters Memory, Anxiety, and Olfactory Behaviors.
D. R. Marks, K. Tucker, M. A. Cavallin, T. G. Mast, and D. A. Fadool (2009)
J. Neurosci. 29, 6734-6751
   Abstract »    Full Text »    PDF »
Switching basal analogue insulins -- short-term weight effects.
E. Ubogagu, Y. Samarasinghe, N. Munro, and M. D Feher (2008)
The British Journal of Diabetes & Vascular Disease 8, 183-186
   Abstract »    PDF »
Pro-Opiomelanocortin Modulates the Thermogenic and Physical Activity Responses to High-Fat Feeding and Markedly Influences Dietary Fat Preference.
Y. C. L. Tung, D. Rimmington, S. O'Rahilly, and A. P. Coll (2007)
Endocrinology 148, 5331-5338
   Abstract »    Full Text »    PDF »
Insulin Treatment and the Problem of Weight Gain in Type 2 Diabetes.
C. Carver (2006)
The Diabetes Educator 32, 910-917
   Abstract »    Full Text »    PDF »
Gonadotropin-Releasing Hormone Secretion from Hypothalamic Neurons: Stimulation by Insulin and Potentiation by Leptin.
R. Burcelin, B. Thorens, M. Glauser, R. C. Gaillard, and F. P. Pralong (2003)
Endocrinology 144, 4484-4491
   Abstract »    Full Text »    PDF »
Glycemic index and disease.
F X. Pi-Sunyer (2002)
Am. J. Clinical Nutrition 76, 290S-298
   Abstract »    Full Text »    PDF »

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