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Science 296 (5574): 1819-1820

Copyright © 2002 by the American Association for the Advancement of Science

Putting the Brakes on Regeneration

Lisa McKerracher and Benjamin Ellezam

The recalcitrance of nerves in the central nervous system (CNS) to regenerate has thwarted efforts to treat patients with spinal cord and other CNS injuries. In their Perspective, McKerracher and Ellezam discuss new findings (Goldberg et al.) revealing that a switch from an axonal to a dendritic growth mode during development may carry over into the adult, preventing CNS neurons from regenerating their axons.

The authors are in the Département de Pathologie et Biologie Cellulaire, Université de Montréal, 2900 Edouard-Montpetit, Montréal, Québec, H3T 1J4 Canada. E-mail: mckerral{at}

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