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Science 297 (5578): 63-64

Copyright © 2002 by the American Association for the Advancement of Science

Also see the archival list of Science's Compass: Enhanced Perspectives

CANCER:
Enhanced: Addiction to Oncogenes--the Achilles Heal of Cancer

I. Bernard Weinstein

A series of recent studies are providing tantalizing hints of new therapeutic approaches for combating cancer. In his Perspective, Weinstein discusses new work (Jain et al.) demonstrating that even brief inactivation of an oncogene can permanently reverse the malignant phenotype of some types of tumor.


The author is at the Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA. E-mail: weinstei{at}cancercenter.columbia.edu


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Refocusing the War on Cancer: The Critical Role of Personalized Treatment.
A. Potti, R. L. Schilsky, and J. R. Nevins (2010)
Science Translational Medicine 2, 28cm13
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Oncogenic Signal Transduction Networks in Cancer: Relevance to Cancer Therapy.
E. Bublil, C. R. Pradeep, and Y. Yarden (2010)
Am. Assoc. Cancer Res. Educ. Book 2010, 39-42
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Mitochondrial p32 Protein Is a Critical Regulator of Tumor Metabolism via Maintenance of Oxidative Phosphorylation.
V. Fogal, A. D. Richardson, P. P. Karmali, I. E. Scheffler, J. W. Smith, and E. Ruoslahti (2010)
Mol. Cell. Biol. 30, 1303-1318
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Stat5 is indispensable for the maintenance of bcr/abl-positive leukaemia.
A. Hoelbl, C. Schuster, B. Kovacic, B. Zhu, M. Wickre, M. A. Hoelzl, S. Fajmann, F. Grebien, W. Warsch, G. Stengl, et al. (2010)
EMBO Mol Med. 2, 98-110
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Serious Hematologic Complications Following Erlotinib Treatment.
G. P. STATHOPOULOS, D. TRAFALIS, A. ATHANASIOU, G. BARDI, and H. CHANDRINOU (2010)
Anticancer Res 30, 973-976
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Small-molecule signal-transduction inhibitors: targeted therapeutic agents for single-gene disorders.
D. M. Davies and J. R. Sampson (2010)
J. Med. Genet. 47, 145-149
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Clinical Definition of Acquired Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Non-Small-Cell Lung Cancer.
D. Jackman, W. Pao, G. J. Riely, J. A. Engelman, M. G. Kris, P. A. Janne, T. Lynch, B. E. Johnson, and V. A. Miller (2010)
J. Clin. Oncol. 28, 357-360
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