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Science 297 (5579): 200-201

Copyright © 2002 by the American Association for the Advancement of Science

PARP-1--a Perpetrator of Apoptotic Cell Death?

Alberto Chiarugi and Michael A. Moskowitz

The caspase-dependent pathway of programmed cell death has been well documented. In their Perspective, Chiarugi and Moskowitz report on new findings (Yu et al.) that reveal a caspase-independent pathway of apoptosis driven by the nuclear enzyme PARP-1.

A. Chiarugi is in the Department of Preclinical and Clinical Pharmacology, University of Florence, 50139 Florence, Italy, and the Department of Cellular and Molecular Physiology, University of Massachusetts Medical School, Worcester, MA 01655, USA. E-mail: alberto.chiarugi{at} M. A. Moskowitz is at the Neuroscience Center, Departments of Radiology, Neurology, and Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA. E-mail: moskowitz{at}

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Nuclear Poly(ADP-ribose) Polymerase-1 Rapidly Triggers Mitochondrial Dysfunction.
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