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Science 297 (5582): 778-779

Copyright © 2002 by the American Association for the Advancement of Science

CMV Makes a Timely Exit

Veronica Sanchez and Deborah H. Spector

DNA viruses must first replicate their genome in the nucleus of the host cell before forming subviral particles that cross into the cytoplasm for the final stages of virion maturation. However, the nuclear envelope provides a physical barrier to the movement of subviral particles into the cytoplasm. In their Perspective, Sanchez and Spector discuss new work (Muranyi et al.) that reveals how cytomegalovirus recruits a host cell protein kinase C to modify the nuclear lamin meshwork of the nuclear envelope, thus enabling subviral particles to exit the nucleus.

The authors are in the Molecular Biology Section and Center for Molecular Genetics, University of California, San Diego, La Jolla, CA 92093, USA. E-mail: dspector{at}

Specific Residues of a Conserved Domain in the N Terminus of the Human Cytomegalovirus pUL50 Protein Determine Its Intranuclear Interaction with pUL53.
J. Milbradt, S. Auerochs, M. Sevvana, Y. A. Muller, H. Sticht, and M. Marschall (2012)
J. Biol. Chem. 287, 24004-24016
   Abstract »    Full Text »    PDF »
Role of the Endoplasmic Reticulum Chaperone BiP, SUN Domain Proteins, and Dynein in Altering Nuclear Morphology during Human Cytomegalovirus Infection.
N. J. Buchkovich, T. G. Maguire, and J. C. Alwine (2010)
J. Virol. 84, 7005-7017
   Abstract »    Full Text »    PDF »
Novel Mode of Phosphorylation-triggered Reorganization of the Nuclear Lamina during Nuclear Egress of Human Cytomegalovirus.
J. Milbradt, R. Webel, S. Auerochs, H. Sticht, and M. Marschall (2010)
J. Biol. Chem. 285, 13979-13989
   Abstract »    Full Text »    PDF »
Phenotypic similarities and differences between UL37-deleted pseudorabies virus and herpes simplex virus type 1.
T. Leege, H. Granzow, W. Fuchs, B. G. Klupp, and T. C. Mettenleiter (2009)
J. Gen. Virol. 90, 1560-1568
   Abstract »    Full Text »    PDF »
Cytomegaloviral proteins that associate with the nuclear lamina: components of a postulated nuclear egress complex.
J. Milbradt, S. Auerochs, H. Sticht, and M. Marschall (2009)
J. Gen. Virol. 90, 579-590
   Abstract »    Full Text »    PDF »
Cytomegaloviral proteins pUL50 and pUL53 are associated with the nuclear lamina and interact with cellular protein kinase C.
J. Milbradt, S. Auerochs, and M. Marschall (2007)
J. Gen. Virol. 88, 2642-2650
   Abstract »    Full Text »    PDF »
Autographa californica Multiple Nucleopolyhedrovirus EXON0 (ORF141) Is Required for Efficient Egress of Nucleocapsids from the Nucleus.
M. Fang, X. Dai, and D. A. Theilmann (2007)
J. Virol. 81, 9859-9869
   Abstract »    Full Text »    PDF »
BFRF1 of Epstein-Barr Virus Is Essential for Efficient Primary Viral Envelopment and Egress.
A. Farina, R. Feederle, S. Raffa, R. Gonnella, R. Santarelli, L. Frati, A. Angeloni, M. R. Torrisi, A. Faggioni, and H.-J. Delecluse (2005)
J. Virol. 79, 3703-3712
   Abstract »    Full Text »    PDF »
Entry of Pseudorabies Virus: an Immunogold-Labeling Study.
H. Granzow, B. G. Klupp, and T. C. Mettenleiter (2005)
J. Virol. 79, 3200-3205
   Abstract »    Full Text »    PDF »
Global Analysis of Host Cell Gene Expression Late during Cytomegalovirus Infection Reveals Extensive Dysregulation of Cell Cycle Gene Expression and Induction of Pseudomitosis Independent of US28 Function.
L. Hertel and E. S. Mocarski (2004)
J. Virol. 78, 11988-12011
   Abstract »    Full Text »    PDF »

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