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Science 297 (5582): 781-783

Copyright © 2002 by the American Association for the Advancement of Science

Riding the Crest of the Wnt Signaling Wave

Paul Trainor and Robb Krumlauf

Formation of the neural crest is a crucial step during the embryonic development of vertebrates, but the signals that direct neural crest induction are largely unknown. In their Perspective, Trainor and Krumlauf discuss new findings (García-Castro et al.) revealing that Wnt6 expression in the surface ectoderm directs neural crest induction.

The authors are at the Stowers Institute for Medical Research, Kansas City, MO 64110, USA. E-mail: rek{at}, pat{at}

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