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Science 297 (5583): 948-949

Copyright © 2002 by the American Association for the Advancement of Science

History Matters

Nicholas T. Ingolia and Andrew W. Murray

How do signaling networks within cells communicate with each other in order to respond to a vast array of external stimuli with the correct responses? In their Perspective, Ingolia and Murray discuss a new approach (Bhalla et al.) that elucidates the regulation of the MAPK signaling cascade in cultured cells and how cellular history contributes to this regulation.

The authors are in the Department of Molecular and Cellular Biology and Bauer Center for Genomics Research, Harvard University, Cambridge, MA 02138, USA. E-mail: amurray{at}

Antitumor Efficacy of the Novel RAF Inhibitor GDC-0879 Is Predicted by BRAFV600E Mutational Status and Sustained Extracellular Signal-Regulated Kinase/Mitogen-Activated Protein Kinase Pathway Suppression.
K. P. Hoeflich, S. Herter, J. Tien, L. Wong, L. Berry, J. Chan, C. O'Brien, Z. Modrusan, S. Seshagiri, M. Lackner, et al. (2009)
Cancer Res. 69, 3042-3051
   Abstract »    Full Text »    PDF »
Short-Term Exposure of Renal Proximal Tubules to Gentamicin Increases Long-Term Multidrug Resistance Protein 2 (Abcc2) Transport Function and Reduces Nephrotoxicant Sensitivity.
S. Notenboom, D. S. Miller, L. H. Kuik, P. Smits, F. G. M. Russel, and R. Masereeuw (2005)
J. Pharmacol. Exp. Ther. 315, 912-920
   Abstract »    Full Text »    PDF »
Expression profiling reveals functionally important genes and coordinately regulated signaling pathway genes during in vitro angiogenesis.
C. N. Hahn, Z. J. Su, C. J. Drogemuller, A. Tsykin, S. R. Waterman, P. J. Brautigan, S. Yu, G. Kremmidiotis, A. Gardner, P. J. Solomon, et al. (2005)
Physiol Genomics 22, 57-69
   Abstract »    Full Text »    PDF »
Simulation Methods for Optimal Experimental Design in Systems Biology.
D. Faller, U. Klingmuller, and J. Timmer (2003)
SIMULATION 79, 717-725
   Abstract »    PDF »
Aspects of Plant Intelligence.
A. TREWAVAS (2003)
Ann. Bot. 92, 1-20
   Abstract »    Full Text »    PDF »

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