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Growth-inhibitory molecules present in the myelin sheath surrounding CNS neurons prevent the regeneration of injured nerve fibers. In a Perspective, Woolf and Bloechlinger discuss new findings published here (Liu et al.) and elsewhere revealing that three of these growth-inhibitory molecules all bind to the same receptor. This suggests that blocking this receptor may be a good therapeutic approach to promoting neuronal regeneration.
The authors are in the Neural Plasticity Research Group, Department of Anesthesia, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA. E-mail: woolf.clifford{at} mgh.harvard.edu
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