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Science 297 (5584): 1132-1134

Copyright © 2002 by the American Association for the Advancement of Science

Also see the archival list of Science's Compass: Enhanced Perspectives

Enhanced: It Takes More Than Two to Nogo

Clifford J. Woolf and Stefan Bloechlinger [HN21]

Growth-inhibitory molecules present in the myelin sheath surrounding CNS neurons prevent the regeneration of injured nerve fibers. In a Perspective, Woolf and Bloechlinger discuss new findings published here (Liu et al.) and elsewhere revealing that three of these growth-inhibitory molecules all bind to the same receptor. This suggests that blocking this receptor may be a good therapeutic approach to promoting neuronal regeneration.

The authors are in the Neural Plasticity Research Group, Department of Anesthesia, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA. E-mail: woolf.clifford{at}

Suppression of p75NTR Does Not Promote Regeneration of Injured Spinal Cord in Mice.
X.-Y. Song, J.-h. Zhong, X. Wang, and X.-F. Zhou (2004)
J. Neurosci. 24, 542-546
   Abstract »    Full Text »    PDF »
Rho activation patterns after spinal cord injury and the role of activated Rho in apoptosis in the central nervous system.
C. I. Dubreuil, M. J. Winton, and L. McKerracher (2003)
J. Cell Biol. 162, 233-243
   Abstract »    Full Text »    PDF »
Characterization of the WAVE1 Knock-Out Mouse: Implications for CNS Development.
J. P. Dahl, J. Wang-Dunlop, C. Gonzales, M. E. P. Goad, R. J. Mark, and S. P. Kwak (2003)
J. Neurosci. 23, 3343-3352
   Abstract »    Full Text »    PDF »
Neurogenesis and Apoptotic Cell Death.
M. A. Moskowitz and E. H. Lo (2003)
Stroke 34, 324-326
   Full Text »    PDF »

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