Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.
BIOCHEMISTRY: Sense and Sensitivity--Controlling the Ribosome
Matthew S. Sachs and Adam P. Geballe
What regulates the ribosome, the protein synthesis factory of the cell? In a Perspective, Sachs and Geballe discuss new findings (Gong and Yanofsky) that reveal how certain newly forming peptides are able to halt the ribosome from within, for the purpose of controlling gene expression.
M. S. Sachs is in the Department of Biochemistry and Molecular Biology, OGI School of Science and Engineering, Oregon Health and Science University, Beaverton, OR 97006, USA. E-mail: msachs{at}bmb.ogi.edu. A. P. Geballe is in the Division of Human Biology, Fred Hutchinson Cancer Center and the University of Washington, Seattle, WA 98109, USA. E-mail: ageballe{at}fhcrc.org.
The editors suggest the following Related Resources on Science sites:
In Science Magazine
REPORTS
Feng Gong and Charles Yanofsky (13 September 2002) Science297 (5588), 1864.
[DOI: 10.1126/science.1073997] |Abstract »|Full Text »|PDF »
Crucial elements that maintain the interactions between the regulatory TnaC peptide and the ribosome exit tunnel responsible for Trp inhibition of ribosome function.
A. K. Martinez, N. H. Shirole, S. Murakami, M. J. Benedik, M. S. Sachs, and L. R. Cruz-Vera (2012)
Nucleic Acids Res.
40, 2247-2257
|Abstract »|Full Text »|PDF »
A nascent polypeptide domain that can regulate translation elongation.
