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Science 297 (5588): 1820-1821

Copyright © 2002 by the American Association for the Advancement of Science

Sense and Sensitivity--Controlling the Ribosome

Matthew S. Sachs and Adam P. Geballe

What regulates the ribosome, the protein synthesis factory of the cell? In a Perspective, Sachs and Geballe discuss new findings (Gong and Yanofsky) that reveal how certain newly forming peptides are able to halt the ribosome from within, for the purpose of controlling gene expression.

M. S. Sachs is in the Department of Biochemistry and Molecular Biology, OGI School of Science and Engineering, Oregon Health and Science University, Beaverton, OR 97006, USA. E-mail: msachs{at} A. P. Geballe is in the Division of Human Biology, Fred Hutchinson Cancer Center and the University of Washington, Seattle, WA 98109, USA. E-mail: ageballe{at}

Crucial elements that maintain the interactions between the regulatory TnaC peptide and the ribosome exit tunnel responsible for Trp inhibition of ribosome function.
A. K. Martinez, N. H. Shirole, S. Murakami, M. J. Benedik, M. S. Sachs, and L. R. Cruz-Vera (2012)
Nucleic Acids Res. 40, 2247-2257
   Abstract »    Full Text »    PDF »
A nascent polypeptide domain that can regulate translation elongation.
P. Fang, C. C. Spevak, C. Wu, and M. S. Sachs (2004)
PNAS 101, 4059-4064
   Abstract »    Full Text »    PDF »
Antagonistic signals within the COX2 mRNA coding sequence control its translation in Saccharomyces cerevisiae mitochondria.
E. H. WILLIAMS and T. D. FOX (2003)
RNA 9, 419-431
   Abstract »    Full Text »    PDF »

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