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Science 298 (5595): 977-979

Copyright © 2002 by the American Association for the Advancement of Science

IMMUNOLOGY:
Versatile Defensins

Tomas Ganz

Defensins are antimicrobial peptides produced by immune cells in response to bacterial infection. In his Perspective, Ganz now reveals several new activities for these peptides including the blocking of human host cell invasion by HIV (Zhang et al.) and the induction of cell-mediated immune responses against tumors in mice (Biragyn et al.).


The author is in the Department of Medicine, University of California, Los Angeles, CA 90095, USA. E-mail: tganz{at}mednet.ucla.edu


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Identification and Biological Characterization of Mouse {beta}-Defensin 14, the Orthologue of Human {beta}-Defensin 3.
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Chicken cathelicidin-B1, an antimicrobial guardian at the mucosal M cell gateway.
R. Goitsuka, C.-l. H. Chen, L. Benyon, Y. Asano, D. Kitamura, and M. D. Cooper (2007)
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Human {beta}-Defensin-1, a Potential Chromosome 8p Tumor Suppressor: Control of Transcription and Induction of Apoptosis in Renal Cell Carcinoma..
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Proteus mirabilis ZapA Metalloprotease Degrades a Broad Spectrum of Substrates, Including Antimicrobial Peptides.
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IL-17 Markedly Up-Regulates {beta}-Defensin-2 Expression in Human Airway Epithelium via JAK and NF-{kappa}B Signaling Pathways.
C.-Y. Kao, Y. Chen, P. Thai, S. Wachi, F. Huang, C. Kim, R. W. Harper, and R. Wu (2004)
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Multidimensional signatures in antimicrobial peptides.
N. Y. Yount and M. R. Yeaman (2004)
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Innate immunity in the lung: how epithelial cells fight against respiratory pathogens.
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ESP13.2, a Member of the {beta}-Defensin Family, Is a Macaque Sperm Surface-Coating Protein Involved in the Capacitation Process.
A. I. Yudin, T. L. Tollner, M.-W. Li, C. A. Treece, J. W. Overstreet, and G. N. Cherr (2003)
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Mysterious CD8 Antiviral Factor Unmasked.
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