Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Subscribe

Logo for

Science 298 (5596): 1184-1186

Copyright © 2002 by the American Association for the Advancement of Science

NEUROBIOLOGY:
A Glial Spin on Neurotrophins

Barbara L. Hempstead and James L. Salzer

Glial cells in the nervous system are responsible for ensheathing the axons of neurons in myelin. However, the positive and negative signals regulating myelination remain obscure. In a Perspective, Hempstead and Salzer discuss new work (Cosgaya et al.) that identifies the neurotrophin BDNF and its receptor p75 as positive modulators of myelination by Schwann cells in the peripheral nervous system.


B. L. Hempstead is in the Department of Medicine, Weill Medical College of Cornell University, New York, NY 10021, USA. E-mail: blhempst{at}med.Cornell.edu. J. L. Salzer is in the Department of Cell Biology and Department of Neurology, New York University School of Medicine, New York, NY 10016, USA. E-mail: jim.salzer{at}med.nyu.edu.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
ProBDNF Induces Neuronal Apoptosis via Activation of a Receptor Complex of p75NTR and Sortilin.
H. K. Teng, K. K. Teng, R. Lee, S. Wright, S. Tevar, R. D. Almeida, P. Kermani, R. Torkin, Z.-Y. Chen, F. S. Lee, et al. (2005)
J. Neurosci. 25, 5455-5463
   Abstract »    Full Text »    PDF »
Reverse Transcription-PCR Analysis of Laser-Captured Cells Points to Potential Paracrine and Autocrine Actions of Neurotrophins in Pancreatic Cancer.
K. Ketterer, S. Rao, H. Friess, J. Weiss, M. W. Buchler, and M. Korc (2003)
Clin. Cancer Res. 9, 5127-5136
   Abstract »    Full Text »    PDF »

To Advertise     Find Products


Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882