Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Logo for

Science 298 (5596): 1189-1190

Copyright © 2002 by the American Association for the Advancement of Science

Decoding NF-kB Signaling

Alice Y. Ting and Drew Endy

The master transcription factor NF-kB regulates the expression of many target genes. In their Perspective, Ting and Endy discuss a new experiment-driven quantitative model (Hoffmann et al.) that seeks to explain how the NF-kB/IkB signaling pathway is fine-tuned so that it can switch on a series of early and late genes in response to a stimulus such as tumor necrosis factor.

A. Y. Ting is in the Department of Chemistry and D. Endy is in the Division of Biological Engineering and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. E-mail: endy{at}

Deletion of tumor necrosis factor-{alpha} ameliorates neurodegeneration in Sandhoff disease mice.
H. Abo-ouf, A. W. M. Hooper, E. J. White, H. J. J. van Rensburg, B. L. Trigatti, and S. A. Igdoura (2013)
Hum. Mol. Genet. 22, 3960-3975
   Abstract »    Full Text »    PDF »
A stochastic spectral analysis of transcriptional regulatory cascades.
A. M. Walczak, A. Mugler, and C. H. Wiggins (2009)
PNAS 106, 6529-6534
   Abstract »    Full Text »    PDF »
The Physical and Biological Characterization of a Frail Mouse Model.
J. Walston, N. Fedarko, H. Yang, S. Leng, B. Beamer, S. Espinoza, A. Lipton, H. Zheng, and K. Becker (2008)
J Gerontol A Biol Sci Med Sci 63, 391-398
   Abstract »    Full Text »    PDF »
Review: Aspirin and Diabetes Mellitus: revisiting an old player.
C. Manrique, G. Lastra, J. Palmer, M. Gardner, and J. R. Sowers (2008)
Therapeutic Advances in Cardiovascular Disease 2, 37-42
   Abstract »    PDF »
Minimal model of spiky oscillations in NF-{kappa}B signaling.
S. Krishna, M. H. Jensen, and K. Sneppen (2006)
PNAS 103, 10840-10845
   Abstract »    Full Text »    PDF »
Constructing quantitative models from qualitative mutant phenotypes: preferences in selecting sensory organ precursors.
C.-P. Hsu, P.-H. Lee, C.-W. Chang, and C.-T. Lee (2006)
Bioinformatics 22, 1375-1382
   Abstract »    Full Text »    PDF »
Evidence that public database records for many cancer-associated genes reflect a splice form found in tumors and lack normal splice forms.
M. Roy, Q. Xu, and C. Lee (2005)
Nucleic Acids Res. 33, 5026-5033
   Abstract »    Full Text »    PDF »
Stochastic amplification and signaling in enzymatic futile cycles through noise-induced bistability with oscillations.
M. Samoilov, S. Plyasunov, and A. P. Arkin (2005)
PNAS 102, 2310-2315
   Abstract »    Full Text »    PDF »
Oscillations in NF-{kappa}B Signaling Control the Dynamics of Gene Expression.
D. E. Nelson, A. E. C. Ihekwaba, M. Elliott, J. R. Johnson, C. A. Gibney, B. E. Foreman, G. Nelson, V. See, C. A. Horton, D. G. Spiller, et al. (2004)
Science 306, 704-708
   Abstract »    Full Text »    PDF »
Growth hormone-induced blood pressure decrease is associated with increased mRNA levels of the vascular smooth muscle KATP channel.
A. Tivesten, A. Barlind, K. Caidahl, N. Klintland, A. Cittadini, C. Ohlsson, and J. Isgaard (2004)
J. Endocrinol. 183, 195-202
   Abstract »    Full Text »    PDF »
Experimental Design in Systems Biology, Based on Parameter Sensitivity Analysis Using a Monte Carlo Method: A Case Study for the TNF{alpha}-Mediated NF-{kappa} B Signal Transduction Pathway.
K.-H. Cho, S.-Y. Shin, W. Kolch, and O. Wolkenhauer (2003)
SIMULATION 79, 726-739
   Abstract »    PDF »

To Advertise     Find Products

Science Signaling. ISSN 1937-9145 (online), 1945-0877 (print). Pre-2008: Science's STKE. ISSN 1525-8882