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Science 298 (5596): 1189-1190

Copyright © 2002 by the American Association for the Advancement of Science

SIGNAL TRANSDUCTION:
Decoding NF-kB Signaling

Alice Y. Ting and Drew Endy

The master transcription factor NF-kB regulates the expression of many target genes. In their Perspective, Ting and Endy discuss a new experiment-driven quantitative model (Hoffmann et al.) that seeks to explain how the NF-kB/IkB signaling pathway is fine-tuned so that it can switch on a series of early and late genes in response to a stimulus such as tumor necrosis factor.

A. Y. Ting is in the Department of Chemistry and D. Endy is in the Division of Biological Engineering and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. E-mail: endy{at}mit.edu

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