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Science 298 (5602): 2339-2340

Copyright © 2002 by the American Association for the Advancement of Science

Carbon Monoxide and Clocks

Darren Boehning and Solomon H. Snyder

Several gaseous molecules, including nitric oxide and carbon monoxide (CO), are important neurotransmitters. In their Perspective, Boehning and Snyder comment on new work (Dioum et al.) that reveals another important activity for CO, that of modulator of the transcription factor NPAS2, a crucial component of the circadian clock.

The authors are in the Departments of Neuroscience, Pharmacology and Molecular Sciences, and Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. E-mail: ssnyder{at}

Thiol-disulfide Redox Dependence of Heme Binding and Heme Ligand Switching in Nuclear Hormone Receptor Rev-erb{beta}.
N. Gupta and S. W. Ragsdale (2011)
J. Biol. Chem. 286, 4392-4403
   Abstract »    Full Text »    PDF »
Identification of a Thiol/Disulfide Redox Switch in the Human BK Channel That Controls Its Affinity for Heme and CO.
L. Yi, J. T. Morgan, and S. W. Ragsdale (2010)
J. Biol. Chem. 285, 20117-20127
   Abstract »    Full Text »    PDF »
Heme Regulatory Motifs in Heme Oxygenase-2 Form a Thiol/Disulfide Redox Switch That Responds to the Cellular Redox State.
L. Yi, P. M. Jenkins, L. I. Leichert, U. Jakob, J. R. Martens, and S. W. Ragsdale (2009)
J. Biol. Chem. 284, 20556-20561
   Abstract »    Full Text »    PDF »
Rev-erb{alpha}, a Heme Sensor That Coordinates Metabolic and Circadian Pathways.
L. Yin, N. Wu, J. C. Curtin, M. Qatanani, N. R. Szwergold, R. A. Reid, G. M. Waitt, D. J. Parks, K. H. Pearce, G. B. Wisely, et al. (2007)
Science 318, 1786-1789
   Abstract »    Full Text »    PDF »
CO-Sensing Mechanisms.
G. P. Roberts, H. Youn, and R. L. Kerby (2004)
Microbiol. Mol. Biol. Rev. 68, 453-473
   Abstract »    Full Text »    PDF »

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