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Science 299 (5604): 209-210

Copyright © 2003 by the American Association for the Advancement of Science

Lymphatics Make the Break

Rakesh K. Jain and Timothy P. Padera

Two vascular networks-the blood system and the lymphatic system-are required for maintaining tissues in a healthy state. In their Perspective, Jain and Padera discuss new work (Abtahian et al.) that identifies two signaling molecules involved in the separation of the blood and lymphatic networks during embryonic development.

The authors are at the Edwin L. Steele Laboratory of Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. E-mail: jain{at}

Reversible transdifferentiation of blood vascular endothelial cells to a lymphatic-like phenotype in vitro.
L. S. Cooley, M. M. Handsley, Z. Zhou, M. A. Lafleur, C. J. Pennington, E. W. Thompson, E. Poschl, and D. R. Edwards (2010)
J. Cell Sci. 123, 3808-3816
   Abstract »    Full Text »    PDF »
Directed and Systematic Differentiation of Cardiovascular Cells From Mouse Induced Pluripotent Stem Cells.
G. Narazaki, H. Uosaki, M. Teranishi, K. Okita, B. Kim, S. Matsuoka, S. Yamanaka, and J. K. Yamashita (2008)
Circulation 118, 498-506
   Abstract »    Full Text »    PDF »
The relevance of circulating epithelial tumor cells (CETC) for therapy monitoring during neoadjuvant (primary systemic) chemotherapy in breast cancer.
O Camara, M Rengsberger, A Egbe, A Koch, M Gajda, U Hammer, C Jorke, C Rabenstein, M Untch, and K Pachmann (2007)
Ann. Onc. 18, 1484-1492
   Abstract »    Full Text »    PDF »
Toward a Systems Engineering Approach to Cancer Drug Delivery.
M. R. Dreher and A. Chilkoti (2007)
J Natl Cancer Inst 99, 983-985
   Full Text »    PDF »
Lymphatic Neoangiogenesis in Human Kidney Transplants Is Associated with Immunologically Active Lymphocytic Infiltrates.
D. Kerjaschki, H. M. Regele, I. Moosberger, K. Nagy-Bojarski, B. Watschinger, A. Soleiman, P. Birner, S. Krieger, A. Hovorka, G. Silberhumer, et al. (2004)
J. Am. Soc. Nephrol. 15, 603-612
   Abstract »    Full Text »    PDF »
Angiogenesis and Lymphangiogenesis in Tumors: Insights from Intravital Microscopy.
R.K. JAIN (2002)
Cold Spring Harb Symp Quant Biol 67, 239-248
   Abstract »    PDF »

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